Endocrine Abstracts

Introduction: Pregnancy as a state of insulin resistance can predict diabetes development in some women, and is associated with increased risk for adverse outcome of neonate and for mother.Aim: The aim of this study is to analyse pregnancy outcome in relation to a disorder of glucose tolerance during pregnancy.Matherial and methods: The study included 77 healthy pregnant women in third trimester registered in Center for endocrinolo...

The detection and characterization of PTC are based on the evaluation of specific ultrasonographic features of thyroid nodes. However, there is limited data regarding diagnostics without typical malignant-appearing nodules. We report a very rare case of PTC in underlying chronic lymphocytic thyroiditis ultrasonographically manifested with diffuse microcalcification without focal mass. A 22-year-old woman visited our institution complaining of weight loss, general weakness, and...

Anaplastic thyroid carcinoma (ATC) is a rare form of thyroid carcinoma that is associated with an extremely poor prognosis. Ultrasonography (US) and subsequent fine needle aspiration biopsy (FNAB) are the first diagnostic methods in the assessment of a palpable thyroid mass. Nevertheless, some clinical and US features of ATC are not specific. Here, we report on an extremely rare case of ATC masquerading as subacute thyroiditis (SAT).A 40-year-old woman w...

Introduction: Thyroid disorders are the most frequently diagnosed endocrinopathies prevalence of which is highly dependent on geographic region and age of study population.Main objective: Evaluation of thyroid function and thyroid ultrasonographic features in 48–50-year-old people from general population in Lithuania.Methods: During a 1 year period 395 randomly selected 48–50-year-aged men (169) and women (226) were enrol...

Primary hyperparathyroidism (PHPT) is nowadays usually diagnosed as an asymptomatic disease but it might be related with advanced end-organ damage. Parathyroid incidentaloma (PI) is the term describing enlarged parathyroid nodules that are unexpectedly discovered on surgery or by imaging performed for nonparathyroid disorders. The recognition of PI might uncover a clinically significant PHPT with the potential for surgical cure. We retrospectively reviewed patients’ reco...

Thyrotoxic periodic paralysis (TPP) is uncommon complication of Graves’ disease mainly observed in young males of Asian origin. It is rarely seen among white hyperthyroid patients (0.1–0.2%), usually presented as lower extremities muscle weakness of sudden onset, probably cause by hypokalemia. Possible mechanism of hypokalemia is an increased sodium–potassium–adenosine triphosphatase pump activity with consequent massive shift og potassium from extracellula...

Introduction: Diabetic nephropathy is a major complication of diabetes mellitus. Involvement of abnormal nitric oxide (NO) production, both via nitric oxide synthase (NOS) dependent and independent pathways (for example, xantine oxoridoreductase (XOR)) has been discussed. New compounds to treat diabetic nephropathy are searched intensively, some novel dihydropirine class drugs (DHP) have been proposed for this purpose.Aim: To study the changes in NO conc...

Thyroid dysfunction has been linked to reduced fertility. It is known that changes in SHBG and sex steroids are a consistent feature associated with hyper- and hypothyroidism. It is also has reported that women with polycystic ovary syndrome (PCOS) are more insulin-resistant than it would be expected on the basis of their age and BMI. The mechanisms underlying this phenomenon are still not clarified. Hyperandrogenaemia may play a role, but also other factors such as thyroid fu...

BMI over 30 kg/m2 is associated with lowest risk for osteoporosis and hip fracture in both sex. Increased body fat mass is followed with greater hip fracture risk, independently of BMI.Aim: Evaluate risk for osteoporosis in postmenopausal female with BMI 25–29.9 kg/m2 and influence of body fat mass on mineral bone density in overweight women.Material and methods: One hundred postmenopausal female, age 48&...

Objective: Fetuin-A, which is a blood protein produced by liver and promotes bone mineralization, is an independent risk factor for type 2 diabetes. Whether Fetuin-A levels relate to the bone metabolism in type 2 diabetic patients is still not clear. Our study aimed to evaluate the relationship of fetuin-A to the markers of bone metabolism and bone turnover in male and female type 2 diabetic patients.Participants and methods: Eighty type 2 diabetic patie...